Multimodal single-cell analysis of cancer
CALL FOR THE ASSIGNMENT OF NO. 1 RESEARCH FELLOWSHIP
Cancer is a disease intrinsically entangled with complexity. The discovery of novel effective cures requires dealing with this complexity and dramatically benefits from high-resolution methods of investigation: genome-wide, multi-modal, singlecell, and spatially resolved. The project aims to study cancer, particularly hematologic malignancies, with cutting-edge methods that allow coupling extensive data with a high-resolution investigation.
Research lines involve:
a) study of the role of RNA modifications (the epitranscriptome) in hematologic malignancies and its relationship with the epigenome,
b) analysis of single-cell and spatially resolved genome-wide data to understand the molecular architecture of gene expression and its derangement in hematologic tumours.
The project lies within disciplinary areas with a robust scientific-technological vocation and benefits from an international collaboration with the Yale School of Medicine, Section of Hematology, where the candidate will be able to carry out part of his project, and with AIL Trento.
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